PKRRATING THINGS TO KNOW BEFORE YOU BUY

The interfacial residues are hugely conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations support a model wherever activating RNA serves for a scaffold to bind several PKR monomers, raising the

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